Running head: Serotonergic facilitation of IPSC

Layer-specific serotonergic facilitation of IPSC in layer 2/3 pyramidal neurons of the visual cortex.

Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of long-term synaptic plasticity in layer 2/3 of the visual cortex at the end of its critical period in rats. However, the cellular and molecular mechanisms remain unclear. Since inhibitory influence is crucial in the induction of synaptic plasticity, the effect of 5-HT on inhibitory transmission was investigated in layer 2/3 pyramida...

Running head: Serotonin, arousal and memory in Aplysia SEROTONERGIC MODULATION IN APLYSIA: II. CELLULAR AND BEHAVIORAL CONSEQUENCES OF INCREASED SEROTONERGIC TONE

Serotonin (5-HT) plays an important role in sensitization of defensive reflexes in Aplysia, and is also involved in several aspects of arousal, such as the control of locomotion and of heart rate. In the preceding paper, we showed that tail-nerve shock, a noxious stimulus that readily induces sensitization, increases the firing rate of a large number of serotonergic neurons throughout the centr...

Chronic Fluoxetine Microdialysis into the Medullary Raphe Nuclei of the Rat, but not Systemic Administration, Increases the Ventilatory Response to CO2 Running Head: Fluoxetine and Medullary Raphe Chemosensitivity

In conscious rats, focal CO2 stimulation of the medullary raphe increases ventilation, while interference with serotonergic function here decreases the ventilatory response to systemic hypercapnia. We sought to determine whether repeated administration of a selective serotonin reuptake inhibitor in this region would increase the ventilatory response to hypercapnia in unanaesthetized rats. In ra...

RUNNING HEAD : Agency and Motor Facilitation Sense of Agency Primes Manual Motor Responses

Dopamine Modulates the Lateral Giant Neuron and Serotonergic Facilitation in Crayfish

The lateral giant neuron (LG) and neurons in many other animals are modulated by dopamine and serotonin. Though individually the amines have opposite effects on the LG, the previous chapter showed that serotonergic facilitation is “chosen” by the cell when both modulators are present at the same time. Preliminary data showed that serotonin conceals dopaminergic depression when serotonin is appl...